3ʳᵈ Edition of the Cancer R&D World Conference 2027

Abstract

The synthesis of nanoparticles utilizing green techniques is becoming increasingly important due to its low cost, biocompatibility, high productivity, and eco-friendly. Herein, the current work focused on the biosynthesis, characterization, and biological applications of zinc oxide nanoparticles (ZnONPs) from Anabasis articulata, including antioxidant anticancer and larvicidal properties as well as modifications to the phytochemical ingredients. Hence, the tan-nin, phenolic, and flavonoid concentrations of the produced nanoparticle samples were lower than those of the original aqueous extract. When compared to the results of ascorbic acid (12.78 mg/ml), the produced extract of A. articulata and its zinc nanoparticles showed remarkable effi-cacy as antioxidant agents with IC50 values of 27.48 and 69.53 mg/ml, respectively. A normal lung fibroblast cell line (WI-38) and three tumour cells were used to test the compounds' anti-cancer properties. With an IC50 of 21.19 µg/ml, the ZnO-NPs of A. articulata showed the greatest cytotoxicity against HePG-2 cell lines. Additionally, A. articulata zinc nanoparticles showed sig-nificant cytotoxicity against MCF-7 and PC3 tumor cell lines, with IC50 values of 30.91 and 49.32 µg/mL. The biogenic ZnO-NPs had LC50 and LC90 values of 13.64 and 26.23 mg/l, respectively, and are very effective against Aedes aegypti larval instar (III). Additionally, the percentages of larval mortality increased from 28.61% at 5 ppm to 84.69% at 25 ppm after 24 hours post-treatment. The overall results of the study point to the potential of A. articulata as a substi-tute biological agent for potential therapeutic uses in the medical domains and for preventing the proliferation of malarial vector insects.